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	optic neuritis

Disease ID	957
Disease	optic neuritis
Definition	Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
Synonym	neuritides, optic neuritis optic neuritis, optic on - optic neuritis optic neuritides optic neuritis (disorder) optic neuritis [disease/finding] optic neuritis [dup] (disorder) optic neuritis nos optic neuritis nos (disorder) optic neuritis, nos optic neuritis, unspecified unspecified optic neuritis unspecified optic neuritis (disorder)
DOID	DOID:1210
ICD10	ICD10CM:H46.9
UMLS	C0029134
MeSH	D009902
SNOMED-CT	SNOMEDCT_US_2016_09_01:66760008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:74) C0026769 \| multiple sclerosis \| 35 C0027873 \| neuromyelitis optica \| 8 C0011303 \| demyelinating disease \| 5 C0456909 \| blindness \| 4 C0019158 \| hepatitis \| 3 C0029124 \| optic atrophy \| 3 C0392662 \| angiostrongyliasis \| 3 C0014070 \| encephalomyelitis \| 3 C0024141 \| systemic lupus erythematosus \| 2 C0034362 \| q fever \| 2 C0026975 \| myelitis \| 2 C0456909 \| vision loss \| 2 C0021400 \| influenza \| 2 C1527336 \| sjogren's syndrome \| 2 C0019163 \| hepatitis b \| 2 C0038522 \| subacute sclerosing panencephalitis \| 1 C0004943 \| behcet's syndrome \| 1 C0547030 \| visual disturbances \| 1 C0036472 \| scrub typhus \| 1 C0751304 \| parasagittal meningioma \| 1 C0014038 \| encephalitis \| 1 C0547030 \| visual disturbance \| 1 C0023343 \| leprosy \| 1 C0026986 \| myelodysplastic syndrome \| 1 C0007570 \| celiac disease \| 1 C0041296 \| tuberculosis \| 1 C0030353 \| papilloedema \| 1 C0024419 \| macroglobulinemia \| 1 C0019360 \| herpes zoster \| 1 C0042870 \| vitamin d defic \| 1 C0271051 \| macular oedema \| 1 C0220754 \| biotinidase deficiency \| 1 C0035333 \| retinitis \| 1 C0025297 \| viral meningitis \| 1 C0014059 \| acute disseminated encephalomyelitis \| 1 C0206178 \| cytomegalovirus retinitis \| 1 C0334121 \| inflammatory pseudotumor \| 1 C0042721 \| viral hepatitis \| 1 C0024440 \| cystoid macular oedema \| 1 C0014544 \| epilepsy \| 1 C0033953 \| sexual dysfunction \| 1 C0011303 \| demyelinating disorders \| 1 C0032285 \| pneumoniae \| 1 C0007959 \| charcot-marie-tooth disease \| 1 C0019364 \| herpes zoster ophthalmicus \| 1 C0038522 \| subacute sclerosing panencephalitis (sspe) \| 1 C1704214 \| xanthogranuloma \| 1 C0025286 \| meningioma \| 1 C0004943 \| behcet's disease \| 1 C0010346 \| crohn's disease \| 1 C0013990 \| emphysema \| 1 C0021053 \| immune disease \| 1 C0004134 \| ataxia \| 1 C0025289 \| meningitis \| 1 C0271051 \| macular edema \| 1 C0024419 \| waldenstrom macroglobulinemia \| 1 C0039128 \| syphilis \| 1 C0017922 \| gsd iii \| 1 C0036454 \| visual field defect \| 1 C0043324 \| juvenile xanthogranuloma \| 1 C0042384 \| vasculitis \| 1 C0029089 \| ophthalmoplegia \| 1 C0243010 \| viral encephalitis \| 1 C0553662 \| juvenile idiopathic arthritis \| 1 C0043092 \| wegener's granulomatosis \| 1 C0025309 \| meningoencephalitis \| 1 C0270911 \| charcot-marie-tooth disease type 1a \| 1 C0040128 \| thyroid disease \| 1 C0042164 \| uveitis \| 1 C0008049 \| chicken pox \| 1 C0026896 \| myasthenia gravis \| 1 C0032001 \| pituitary apoplexy \| 1 C0409974 \| lupus erythematosus \| 1 C0011303 \| demyelinating diseases \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:1) 823 \| CAPN1 \| CTD_human
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:72) 56 \| ACRV1 \| 1.271 \| DISEASES 199 \| AIF1 \| 1.845 \| DISEASES 273 \| AMPH \| 2.131 \| DISEASES 361 \| AQP4 \| 7.596 \| DISEASES 8874 \| ARHGEF7 \| 1.32 \| DISEASES 627 \| BDNF \| 1.201 \| DISEASES 831 \| CAST \| 1.625 \| DISEASES 930 \| CD19 \| 1.291 \| DISEASES 959 \| CD40LG \| 2.95 \| DISEASES 1043 \| CD52 \| 1.07 \| DISEASES 1041 \| CDSN \| 1.277 \| DISEASES 1117 \| CHI3L2 \| 1.954 \| DISEASES 1270 \| CNTF \| 2.122 \| DISEASES 1351 \| COX8A \| 2.156 \| DISEASES 9547 \| CXCL14 \| 1.699 \| DISEASES 2833 \| CXCR3 \| 1.648 \| DISEASES 51428 \| DDX41 \| 3.2 \| DISEASES 1896 \| EDA \| 1.786 \| DISEASES 30845 \| EHD3 \| 2.007 \| DISEASES 2189 \| FANCG \| 1.536 \| DISEASES 50943 \| FOXP3 \| 1.338 \| DISEASES 2687 \| GGT5 \| 2.05 \| DISEASES 23493 \| HEY2 \| 1.055 \| DISEASES 3115 \| HLA-DPB1 \| 1.331 \| DISEASES 3123 \| HLA-DRB1 \| 1.747 \| DISEASES 3127 \| HLA-DRB5 \| 2.666 \| DISEASES 3339 \| HSPG2 \| 1.53 \| DISEASES 3456 \| IFNB1 \| 4.522 \| DISEASES 3547 \| IGSF1 \| 1.782 \| DISEASES 3586 \| IL10 \| 1.605 \| DISEASES 3605 \| IL17A \| 1.252 \| DISEASES 102723508 \| KANTR \| 1.402 \| DISEASES 81033 \| KCNH6 \| 1.906 \| DISEASES 374654 \| KIF7 \| 1.67 \| DISEASES 84894 \| LINGO1 \| 3.652 \| DISEASES 348801 \| LNP1 \| 1.888 \| DISEASES 4049 \| LTA \| 1.448 \| DISEASES 4099 \| MAG \| 2.636 \| DISEASES 4155 \| MBP \| 5.202 \| DISEASES 142678 \| MIB2 \| 2.135 \| DISEASES 4318 \| MMP9 \| 1.334 \| DISEASES 4336 \| MOBP \| 1.773 \| DISEASES 4340 \| MOG \| 6.362 \| DISEASES 8898 \| MTMR2 \| 1.23 \| DISEASES 4536 \| MT-ND2 \| 1.213 \| DISEASES 4538 \| MT-ND4 \| 4.624 \| DISEASES 4540 \| MT-ND5 \| 1.12 \| DISEASES 4795 \| NFKBIL1 \| 1.521 \| DISEASES 4942 \| OAT \| 1.201 \| DISEASES 8481 \| OFD1 \| 1.298 \| DISEASES 5091 \| PC \| 1.695 \| DISEASES 10687 \| PNMA2 \| 1.984 \| DISEASES 5457 \| POU4F1 \| 3.735 \| DISEASES 5542 \| PRB1 \| 2.611 \| DISEASES 5562 \| PRKAA1 \| 1.313 \| DISEASES 5730 \| PTGDS \| 1.592 \| DISEASES 5996 \| RGS1 \| 1.221 \| DISEASES 6295 \| SAG \| 1.627 \| DISEASES 5275 \| SERPINB13 \| 1.869 \| DISEASES 3177 \| SLC29A2 \| 1.222 \| DISEASES 9301 \| SNORD27 \| 1.959 \| DISEASES 6649 \| SOD3 \| 1.606 \| DISEASES 6656 \| SOX1 \| 1.044 \| DISEASES 6668 \| SP2 \| 1.278 \| DISEASES 6696 \| SPP1 \| 1.892 \| DISEASES 55576 \| STAB2 \| 1.064 \| DISEASES 342898 \| SYCN \| 1.838 \| DISEASES 7124 \| TNF \| 2.709 \| DISEASES 7133 \| TNFRSF1B \| 2.521 \| DISEASES 8266 \| UBL4A \| 4.237 \| DISEASES 134430 \| WDR36 \| 1.169 \| DISEASES 84107 \| ZIC4 \| 1.829 \| DISEASES
Locus	(Waiting for update.)

Disease ID	957
Disease	optic neuritis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:48) HP:0000572 \| Visual loss \| 10 HP:0011096 \| Demyelination \| 5 HP:0000618 \| Blindness \| 4 HP:0002633 \| Vasculitis \| 3 HP:0000648 \| Optic-nerve degeneration \| 3 HP:0012115 \| Liver inflammation \| 3 HP:0012486 \| Inflammation of spinal cord \| 2 HP:0000505 \| Poor vision \| 2 HP:0003447 \| Axonal loss \| 2 HP:0002180 \| Neurodegeneration \| 2 HP:0001123 \| Partial loss of field of vision \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0000603 \| Central scotomata \| 2 HP:0002725 \| Systemic lupus erythematosus \| 2 HP:0001945 \| Fever \| 2 HP:0040049 \| Macular edema \| 2 HP:0000554 \| Uveitis \| 1 HP:0002529 \| Neuronal loss in central nervous system \| 1 HP:0005681 \| Juvenile idiopathic arthritis \| 1 HP:0000969 \| Dropsy \| 1 HP:0006562 \| Viral hepatitis \| 1 HP:0007824 \| Total ophthalmoplegia \| 1 HP:0002664 \| Neoplasia \| 1 HP:0100246 \| Osteoma \| 1 HP:0002597 \| Abnormality of blood vessels \| 1 HP:0100561 \| Spinal cord lesion \| 1 HP:0000602 \| Ophthalmoplegia \| 1 HP:0002383 \| Encephalitis \| 1 HP:0002097 \| Pulmonary emphysema \| 1 HP:0005508 \| Waldenstrom macroglobulinemia \| 1 HP:0007663 \| Central visual loss \| 1 HP:0011505 \| Cystoid macular edema \| 1 HP:0030585 \| Red desaturation \| 1 HP:0000529 \| Slowly progressive visual loss \| 1 HP:0002858 \| Mengiomia \| 1 HP:0000575 \| Scotoma \| 1 HP:0100280 \| Morbus Crohn \| 1 HP:0002863 \| Myelodysplastic syndrome \| 1 HP:0005318 \| Cerebral vasculitis \| 1 HP:0001251 \| Ataxia \| 1 HP:0000970 \| Lack of sweating \| 1 HP:0012531 \| Pain \| 1 HP:0030528 \| Paracentral scotoma \| 1 HP:0002608 \| Celiac disease \| 1 HP:0001287 \| Meningitis \| 1 HP:0000820 \| Thyroid abnormality \| 1 HP:0200123 \| Chronic liver inflammation \| 1 HP:0040078 \| Axonal degeneration \| 1

Disease ID	957
Disease	optic neuritis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:18) C2598155 \| pain C1868685 \| disseminated sclerosis C1417325 \| multiple sclerosis C1290884 \| inflammatory disease C0948402 \| hypertrophic pachymeningitis C0858618 \| dyschromatopsia C0852416 \| pupillary signs C0520998 \| phosphenes C0456909 \| blindness C0235272 \| retinal damage C0234131 \| motor dysfunction C0162293 \| papillitis C0155288 \| papilledema C0036454 \| visual field defects C0036454 \| scotomas C0029440 \| osteoma C0026896 \| myasthenia gravis C0007682 \| disease of the central nervous system
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:10) C0026769 \| multiple sclerosis \| 35 C0456909 \| blindness \| 4 C1290884 \| inflammatory disease \| 3 C0036454 \| visual field defects \| 1 C0030193 \| pain \| 1 C0948402 \| hypertrophic pachymeningitis \| 1 C0234131 \| motor dysfunction \| 1 C0029440 \| osteoma \| 1 C0026896 \| myasthenia gravis \| 1 C0007682 \| disease of the central nervous system \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:0)
(Waiting for update.)

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	957
Disease	optic neuritis
Case	(Waiting for update.)

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